Digestive & GI Medicines

Do not take with:

• Antispasmodic stomach medicines, other stomach medicines containing scopolia extract, and motion sickness medicines.

Do not:

• Drive or operate machinery after taking it. Blurred vision, abnormal sensitivity to light, and similar symptoms may occur.
• Take it while breastfeeding, or breastfeed while taking it. It can pass into breast milk and make the baby's pulse faster.

Instructions for use:

• Ages 15 and over: Chew the tablet or let it dissolve in your mouth. It can be taken without water. Take 1 tablet per dose, up to 3 times a day. Leave at least 4 hours between doses.
• Under 15: Do not take this medicine.
• Follow the dosage directions strictly.
• Press the tablet through the foil on the back of the blister pack to take it out. Swallowing the blister pack by mistake can puncture the lining of the esophagus and cause an accident.

Inactive ingredients:

D-mannitol, cellulose, crospovidone, corn starch, gum arabic, magnesium stearate, aspartame (L-phenylalanine compound), l-menthol, flavoring.

This product uses a crude drug, so the color and taste of the tablets may vary slightly and black specks may be visible. This does not change the effect. The tablets are yellow because berberine tannate is yellow. No coloring is added.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Have diarrhea with a fever, bloody stools, or mucus in the stools that keeps coming.
• Have sudden, severe diarrhea, or diarrhea with abdominal pain, bloating, or nausea. Forcing diarrhea to stop with this medicine can make the illness worse.
• Are pregnant or may be pregnant.
• Are elderly.
• Have had an allergic reaction to a medicine or other substance.
• Have difficulty urinating.
• Have been diagnosed with heart disease or glaucoma.

When to stop and seek advice:

If any of the following appear after taking this medicine, they may be side effects. Stop taking it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, or itching.
• Nervous system: Headache.
• Urinary: Difficulty urinating.
• Other: Facial flushing or abnormal sensitivity to light.

If dry mouth or blurred vision continues or gets worse, stop taking this medicine and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

If symptoms do not improve after 5 to 6 days, stop taking this medicine and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

This medicine may make it harder to produce breast milk.

Storage:

Store in a cool place with low humidity, away from direct sunlight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not use after the expiry date. When separating the blister sheet along the perforations, take care not to damage the foil on the back of tablets you are not taking, as this can spoil them.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert and product page. Stoppa Anti-Diarrheal EX information checked October 1, 2026.

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Do not take with:

• Antispasmodic stomach medicines, other stomach medicines containing scopolia extract, and motion sickness medicines.

Do not:

• Drive or operate machinery after taking it. Blurred vision, abnormal sensitivity to light, and similar symptoms may occur.
• Take it while breastfeeding, or breastfeed while taking it. It can pass into breast milk and make the baby's pulse faster.

Instructions for use:

• Ages 15 and over: Chew the tablet or let it dissolve in your mouth. It can be taken without water. Take 1 tablet per dose, up to 3 times a day. Leave at least 4 hours between doses.
• Under 15: Do not take this medicine.
• Follow the dosage directions strictly.
• Press the tablet through the foil on the back of the blister pack to take it out. Swallowing the blister pack by mistake can puncture the lining of the esophagus and cause an accident.

Inactive ingredients:

D-mannitol, cellulose, crospovidone, corn starch, dextrin, anhydrous silica, magnesium stearate, aspartame (L-phenylalanine compound), l-menthol, flavoring.

This product uses a crude drug, so the color and taste of the tablets may vary slightly and black specks may be visible. This does not change the effect. The tablets are yellow because berberine tannate is yellow. No coloring is added.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Have diarrhea with a fever, bloody stools, or mucus in the stools that keeps coming.
• Have sudden, severe diarrhea, or diarrhea with abdominal pain, bloating, or nausea. Forcing diarrhea to stop with this medicine can make the illness worse.
• Are pregnant or may be pregnant.
• Are elderly.
• Have had an allergic reaction to a medicine or other substance.
• Have difficulty urinating.
• Have been diagnosed with heart disease or glaucoma.

When to stop and seek advice:

If any of the following appear after taking this medicine, they may be side effects. Stop taking it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, or itching.
• Nervous system: Headache.
• Urinary: Difficulty urinating.
• Other: Facial flushing or abnormal sensitivity to light.

If dry mouth or blurred vision continues or gets worse, stop taking this medicine and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

If symptoms do not improve after 5 to 6 days, stop taking this medicine and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

This medicine may make it harder to produce breast milk.

Storage:

Store in a cool place with low humidity, away from direct sunlight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not use after the expiry date. When separating the blister sheet along the perforations, take care not to damage the foil on the back of tablets you are not taking, as this can spoil them.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert and product page. Stoppa L Anti-Diarrheal EX information checked October 1, 2026.

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Do not use:

• If you have had an allergic reaction to this medicine or any of its ingredients.

Do not take with:

• Antispasmodic stomach medicines.

Do not:

• Drive or operate machinery after taking it. Drowsiness may occur.
• Drink alcohol before or after taking it.

Instructions for use:

• Ages 15 and over: Take 1 tablet per dose, 2 times a day. Leave at least 4 hours between doses. If the diarrhea has stopped, do not take it.
• Under 15: Do not take this medicine.
• Follow the dosage directions strictly.
• Press the tablet through the foil on the back of the blister pack to take it out. The tablet is fragile, so press with the pad of your finger, not your nail. Swallowing the blister pack by mistake can puncture the lining of the esophagus and cause an accident.
• When you take the tablet out, the foil can sometimes be cut out in a round disc. If that happens, do not swallow it together with the tablet.
• The tablet may crack or chip. This does not change the effect. Take the broken pieces too. Take the tablet soon after taking it out of the pack.

Inactive ingredients:

Erythritol, D-mannitol, povidone, saccharin sodium, macrogol, magnesium stearate, anhydrous silica, flavoring (including l-menthol).

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Have diarrhea with a fever, bloody stools, or mucus in the stools that keeps coming.
• Have sudden, severe diarrhea, or diarrhea with abdominal pain, bloating, or nausea. Forcing diarrhea to stop with this medicine can make the illness worse.
• Are pregnant or may be pregnant.
• Are breastfeeding.
• Are elderly.
• Have had an allergic reaction to a medicine or other substance.
• Have an anal disorder or a similar condition in which constipation must be avoided. This medicine can cause constipation.

When to stop and seek advice:

If any of the following appear after taking this medicine, they may be side effects. Stop taking it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, or itching.
• Digestive: Constipation, bloating, abdominal discomfort, nausea, abdominal pain, vomiting, or loss of appetite.
• Nervous system: Dizziness.

Rare but serious reactions may occur. Seek medical attention immediately if you develop the following symptoms:

• Shock (anaphylaxis): Itchy skin, hives, a hoarse voice, sneezing, an itchy throat, difficulty breathing, palpitations, or clouded consciousness soon after taking the medicine.
• Ileus-like symptoms (like a bowel obstruction): Severe abdominal pain, stopping of the passing of gas, vomiting, or marked constipation with abdominal bloating.
• Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis): High fever, red eyes, eye discharge, sore lips, sore throat, or a widespread rash or redness that persists or suddenly worsens.

If constipation continues or gets worse, stop taking this medicine and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

If symptoms do not improve after 2 to 3 days, stop taking this medicine and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Storage:

Store in a cool place with low humidity, away from direct sunlight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not take it after the expiry date or, for household-delivery sales (配置販売), after the end of the placement period. If the tablet is left somewhere humid it may soften. This does not change the effect.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert, revised April 2013, and the product page. Loperamac Satto information checked October 1, 2026.

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Do not take with:

• Stomach pain or antispasmodic medicines (胃腸鎮痛鎮痙薬).
• Other stomach medicines containing scopolia extract (ロートエキス).
• Motion sickness medicines.

Do not:

• Drive or operate machinery after taking it. Blurred vision, unusual glare, and similar symptoms may occur.
• Take it while breastfeeding, or avoid breastfeeding if you do take it. It can pass into breast milk and make the baby's pulse faster.

Instructions for use:

Take after meals, with water or hot water.

• Ages 15 and over: Take 3 tablets per dose, 3 times a day.
• Ages 11 to 14: Take 2 tablets per dose, 3 times a day.
• Under 11: Do not take this medicine.
• Follow the dosage directions strictly.
• If a child takes it, an adult must supervise and guide.
• Press the raised part of the tablet on the blister sheet firmly with your fingertip to break the foil on the back, then take the tablet out. Swallowing the sheet by mistake can pierce the esophagus and cause an accident.

Inactive ingredients:

Corn starch, maltose syrup powder (アメ粉), carmellose calcium, talc, magnesium stearate.

This is a product made with herbal ingredients (生薬), so the color and taste of the tablets can differ a little between products. This does not change the effect.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Have diarrhea with a fever, bloody stools, or mucus in the stools that keeps coming.
• Have sudden, severe diarrhea, or diarrhea with abdominal pain, bloating, or nausea. Forcing diarrhea to stop with this medicine can make the illness worse.
• Are pregnant or may be pregnant.
• Are elderly.
• Have had an allergic reaction to a medicine or other substance.
• Have difficulty urinating.
• Have been diagnosed with heart disease or glaucoma.
• Are taking an oral medicine that contains a parasympathetic blocker (副交感神経遮断剤), such as belladonna total alkaloids, isopropamide iodide, or scopolia extract.

When to stop and seek advice:

If any of the following appear after taking this medicine, they may be side effects. Stop taking it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, or itching.
• Nervous system: Headache.
• Urinary: Difficulty urinating.
• Other: Flushed face or unusual glare.

If dry mouth or blurred vision appears and keeps up or gets worse, stop taking this medicine and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

If symptoms do not improve after 5 to 6 days, stop taking this medicine and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Other: Breast milk production may decrease.

Storage:

Store in a cool place with low humidity, away from direct sunlight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Take care not to damage the foil on the back of the tablets. The tablets absorb moisture easily, which can discolor them or change their quality. Do not take a discolored tablet. Do not take it after the expiry date. Even within the expiry date, take it within 6 months of opening, to keep the quality. Write the date you opened the inner foil bag in the “opened on” (開封年月日) box on the carton.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert and the product page. Biofermin Antidiarrheal information checked October 1, 2026.

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Classification:

The package insert labels it as a designated quasi-drug (指定医薬部外品) and an intestinal regulator (整腸薬). It does not carry a 第1類, 第2類, or 第3類 medicine class.

Instructions for use:

Take after meals.

• Ages 15 and over: Take 3 tablets per dose, 3 times a day.
• Ages 5 to 14: Take 2 tablets per dose, 3 times a day.
• Under 5: Do not give this medicine.
• Follow the dosage directions strictly.
• If a child takes it, an adult must supervise and guide.
• Do not give it to children under 5, as the tablet can catch in the throat.
• Do not put a tablet back in the bottle if you have touched it with wet hands. This can discolor it or change its quality.

When you first open the bottle:

• Peel off the seal on the mouth of the bottle and throw it away.
• Take out the padding and throw it away. The padding is there to stop the tablets breaking in transit. If you put it in and out of the bottle, it can take in moisture and change the quality, or bring in foreign matter.

Inactive ingredients:

Corn starch, dextrin, lactose hydrate, precipitated calcium carbonate, maltose syrup powder (アメ粉), white sugar, talc, magnesium stearate.

Consult a doctor or pharmacist before use if you:

• Are receiving treatment from a doctor.

When to stop and seek advice:

If your symptoms have not improved after taking it for about 1 month, stop taking it at once and consult a doctor or pharmacist, taking the package insert with you.

Storage:

Store in a cool place with low humidity, away from direct sunlight, with the cap shut tight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not take it after the expiry date. Even within the expiry date, take it within 6 months of opening, to keep the quality. Close the cap firmly after every dose, as the tablets can pick up other smells or absorb moisture and change in quality. Write the date you opened the bottle in the “opened on” (開封年月日) box on the carton and the bottle.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert for the 130-, 350-, 540-, and 550-tablet bottles, and the product page. New Biofermin S information checked October 1, 2026.

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Instructions for use:

Take after meals, with water or hot water.

• Ages 15 and over: Take 2 tablets per dose, 3 times a day.
• Under 15: Do not take this medicine.
• Follow the dosage directions strictly.
• Do not put a tablet back in the bottle if you have touched it with wet hands. This can discolor it or change its quality.

Inactive ingredients:

Corn starch, reduced maltose syrup (還元麦芽糖水アメ), carmellose calcium, erythritol, magnesium stearate, aspartame (L-phenylalanine compound), anhydrous silicic acid.

About the ingredients:

• If you are due for a urine or stool test, tell your doctor you are taking this medicine. It can affect the test values.
• Your urine may turn yellow. This is from the vitamin B2 (riboflavin) and is nothing to worry about.
• Some tablets may show red spots from the vitamin B2 (riboflavin). This does not change the effect.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Have been diagnosed with phenylketonuria (フェニルケトン尿症).

When to stop and seek advice:

If any of the following appear after taking this medicine, it may be a side effect. Stop taking it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Digestive: Nausea or vomiting.

If diarrhea appears and keeps up or gets worse, stop taking this medicine and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

If symptoms have not improved after taking it for about 1 month, stop taking it and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Storage:

Store in a cool place with low humidity, away from direct sunlight, with the cap shut tight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Throw away the padding in the bottle once you have opened the cap. It is there to stop the tablets breaking in transit, and putting it in and out of the bottle can make it take in moisture and change the quality, or bring in foreign matter. Do not take it after the expiry date. Even within the expiry date, take it within 6 months of opening, to keep the quality. Close the cap firmly after every dose, as the tablets can pick up other smells or absorb moisture and change in quality. Write the date you opened the bottle in the “opened on” (開封年月日) box on the carton and the bottle.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert and the product page. Biofermin VC information checked October 1, 2026.

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Instructions for use:

• Ages 15 and over: Take 1 tablet per dose, 3 times a day, before meals or between meals (食前又は食間). Chew it or let it dissolve in your mouth.
• Under 15: Do not take this medicine.
• Follow the dosage directions strictly.
• You must chew the tablet or let it dissolve in your mouth.
• “Between meals” (食間) means between one meal and the next, about 2 to 3 hours after a meal.
• Press the raised part of the tablet on the blister sheet firmly with your fingertip to break the foil on the back, then take the tablet out. Swallowing the sheet by mistake can pierce the esophagus and cause an accident.

The manufacturer's product page describes it as a chewable tablet with a yogurt flavor that you take without water.

Inactive ingredients:

Lactitol, cellulose, anhydrous silicic acid, croscarmellose sodium (クロスCMC-Na), magnesium stearate, carmellose sodium (CMC-Na), flavoring.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Have had an allergic reaction to a medicine or other substance.

When to stop and seek advice:

If any of the following appear after taking this medicine, it may be a side effect. Stop taking it at once and consult a doctor, pharmacist, or registered salesperson, taking the box with you:

• Skin: Rash, redness, or itching.

If diarrhea appears and keeps up or gets worse, stop taking this medicine and consult a doctor, pharmacist, or registered salesperson, taking the box with you.

If symptoms have not improved after taking it for about 2 weeks, stop taking it and consult a doctor, pharmacist, or registered salesperson, taking the box with you.

Storage:

Store in a cool place with low humidity, away from direct sunlight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not take it after the expiry date, which is printed on the bottom of the package.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert and the product page. Gas Pitan information checked October 1, 2026.

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Classification:

Designated Class 2 medicine (指定第2類医薬品). On the box and the package insert it is printed as 第2類医薬品 with the 2 inside a square. The manufacturer describes this as a Class 2 medicine that needs special attention: check the “do not use” section and consult a pharmacist or registered salesperson before use.

Do not use:

• If you have had an allergic reaction to this medicine or any of its ingredients.
• If the affected area is festering with pus.

Do not:

• Use it for a long time.

Instructions for use:

To inject it into the anus: Put the nozzle into the anus and inject the whole amount slowly.

• Ages 15 and over: 1 applicator per dose, 1 to 2 times a day.
• Under 15: Do not use this medicine.
• Take off the cap and push a little ointment out of the tip of the nozzle.
• Put the nozzle into the anus, press the body of the applicator, and inject slowly. Pull it out while still pressing.
• Put in only the nozzle.

To apply it to the skin around the anus: Apply the following amount to the area. Once you have used an applicator to apply the ointment, do not use it to inject.

• Ages 15 and over: A suitable amount, 1 to 3 times a day.
• Under 15: Do not use this medicine.
• Take off the cap, take an amount that covers the affected area onto a clean finger, and apply it as it is, or spread it on gauze and stick that on the area.
• If cold weather or cold storage has made the ointment hard to squeeze, hold the applicator in your hand to warm it. It will soften.

Follow the dosage directions strictly. Use only on the anus. The manufacturer says using it after a bowel movement, after a bath, or before going to sleep is effective. A small amount of ointment stays in the applicator because it is an injection type. The manufacturer fills each applicator with that in mind.

Inactive ingredients:

White petrolatum, medium-chain fatty acid triglyceride, glyceryl monostearate. The ointment is white to slightly yellowish white.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Are pregnant or may be pregnant.
• Have had an allergic reaction to a medicine or other substance.

When to stop and seek advice:

If any of the following appear after using this medicine, they may be side effects. Stop using it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, itching, or swelling.
• Other: A stinging or irritated feeling, or festering with pus.

Rare but serious reactions may occur. Seek medical attention immediately if you develop the following symptoms:

• Shock (anaphylaxis): Itchy skin, hives, a hoarse voice, sneezing, an itchy throat, difficulty breathing, palpitations, or clouded consciousness soon after using the medicine.

If symptoms have not improved after using it for about 10 days, stop using it and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Storage:

Store in a cool place away from direct sunlight, with the cap on. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not use it after the expiry date. Do not flush used applicators or their bags down the toilet. The ointment is oil-based, so it can be hard to remove if it gets on clothes.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert (revised April 2017) and the product page. Borraginol A Injection Ointment information checked October 1, 2026.

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Classification:

Designated Class 2 medicine (指定第2類医薬品). On the box and the package insert it is printed as 第2類医薬品 with the 2 inside a square. The manufacturer describes this as a Class 2 medicine that needs special attention: check the “do not use” section and consult a pharmacist or registered salesperson before use.

Do not use:

• If you have had an allergic reaction to this medicine or any of its ingredients.
• If the affected area is festering with pus.

Do not:

• Use it for a long time.

Instructions for use:

Take off the wrapping and insert the suppository into the anus.

• Ages 15 and over: Use 1 suppository per dose, 1 to 2 times a day.
• Under 15: Do not use this medicine.
• If the suppository is soft, cool it for a while before use. If cold weather or cold storage has made the surface too hard, warm it in your hand until the surface is smooth before use.
• Use only in the anus.
• Follow the dosage directions strictly.
• The manufacturer says insertion after a bowel movement, after a bath, or before going to sleep is effective.

How to take it out and insert it:

• Cut one suppository off the aluminum strip.
• Pinch the top of the aluminum sheet, one side in each hand.
• Open it out to the left and right and take the suppository out. Take care not to cut your fingers on the aluminum sheet.
• Hold the base of the suppository and push it in with your finger, tip first, until it is fully inside the anus.

After inserting:

• To stop the suppository coming out, avoid strenuous movement straight after inserting it.
• You may feel something foreign in the anus after inserting it. This fades as the suppository melts.
• You may pass something oily in the next bowel movement. This is the oil-based base that has melted, and is nothing to worry about.

Inactive ingredients:

Hard fat (ハードファット). The suppository is white to slightly yellowish white, and comes in an aluminum sheet.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Are pregnant or may be pregnant.
• Have had an allergic reaction to a medicine or other substance.

When to stop and seek advice:

If any of the following appear after using this medicine, they may be side effects. Stop using it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, itching, or swelling.
• Other: A stinging or irritated feeling, or festering with pus.

Rare but serious reactions may occur. Seek medical attention immediately if you develop the following symptoms:

• Shock (anaphylaxis): Itchy skin, hives, a hoarse voice, sneezing, an itchy throat, difficulty breathing, palpitations, or clouded consciousness soon after using the medicine.

If symptoms have not improved after using it for about 10 days, stop using it and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Storage:

Store at 1 to 30°C. It is designed to melt at body temperature, so keep it in a cool place away from direct sunlight. Even after opening, put the suppositories back in the outer box with the tips pointing down, and store the box standing upright as the mark on it shows. Avoid storing it at 0°C or below, which can cause cracks. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not use it after the expiry date. A melted suppository can leak out after insertion and be hard to remove from clothes.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert (revised April 2017) and the product page. Borraginol A Suppositories information checked October 1, 2026.

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Classification:

Designated Class 2 medicine (指定第2類医薬品). On the box and the package insert it is printed as 第2類医薬品 with the 2 inside a square. The manufacturer describes this as a Class 2 medicine that needs special attention: check the “do not use” section and consult a pharmacist or registered salesperson before use.

Do not use:

• If you have had an allergic reaction to this medicine or any of its ingredients.
• If the affected area is festering with pus.

Do not:

• Use it for a long time.

Instructions for use:

• Ages 15 and over: Apply a suitable amount, 1 to 3 times a day. Apply it directly to the affected area, or spread it on gauze and stick that on the area.
• Under 15: Do not use this medicine.
• Use only on the anus.
• Follow the dosage directions strictly.
• Take an amount that covers the affected area onto a clean finger and apply it as it is, or spread it on gauze.
• To open the tube, turn the cap around and press the raised part of the cap firmly onto the tip of the tube.
• If the ointment has become hard to squeeze because of cold weather or cold storage, hold the tube in your hand to warm it. It will soften.

Inactive ingredients:

White petrolatum, medium-chain fatty acid triglyceride, glyceryl monostearate. The ointment is white to slightly yellowish white.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Are pregnant or may be pregnant.
• Have had an allergic reaction to a medicine or other substance.

When to stop and seek advice:

If any of the following appear after using this medicine, they may be side effects. Stop using it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, itching, or swelling.
• Other: A stinging or irritated feeling, or festering with pus.

If symptoms have not improved after using it for about 10 days, stop using it and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Storage:

Store in a cool place away from direct sunlight, with the cap shut tight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not use it after the expiry date. The ointment is oil-based, so it can be hard to remove if it gets on clothes. Do not bend the tube back and forth repeatedly, as it can tear.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert (revised April 2017) and the product page. Borraginol A Ointment information checked October 1, 2026.

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Classification:

Class 2 medicine (第2類医薬品). It is not the designated Class 2 (指定第2類) that the Borraginol A products carry.

Do not use:

• If you have had an allergic reaction to this medicine or any of its ingredients.

Do not:

• Use it for a long time.

Instructions for use:

Take off the wrapping and insert the suppository into the anus.

• Ages 15 and over: Use 1 suppository per dose, 1 to 2 times a day.
• Under 15: Do not use this medicine.
• If the suppository is soft, cool it for a while before use. If cold weather or cold storage has made the surface too hard, warm it in your hand until the surface is smooth before use.
• Use only in the anus.
• Follow the dosage directions strictly.
• The manufacturer says insertion after a bowel movement, after a bath, or before going to sleep is effective.

How to take it out and insert it:

• Cut one suppository off the aluminum strip.
• Pinch the top of the aluminum sheet, one side in each hand.
• Open it out to the left and right and take the suppository out. Take care not to cut your fingers on the aluminum sheet.
• Hold the base of the suppository and push it in with your finger, tip first, until it is fully inside the anus.

After inserting:

• To stop the suppository coming out, avoid strenuous movement straight after inserting it.
• You may feel something foreign in the anus after inserting it. This fades as the suppository melts.
• You may pass something oily in the next bowel movement. This is the oil-based base that has melted, and is nothing to worry about.

Inactive ingredients:

Hard fat (ハードファット). The suppository is white to slightly yellowish white, and comes in an aluminum sheet.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Are pregnant or may be pregnant.
• Are elderly.
• Have had an allergic reaction to a medicine or other substance.
• Have swelling (むくみ).
• Have been diagnosed with kidney disease, high blood pressure, or heart disease.

When to stop and seek advice:

If any of the following appear after using this medicine, they may be side effects. Stop using it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, itching, or swelling.
• Other: A stinging or irritated feeling.

Rare but serious reactions may occur. Seek medical attention immediately if you develop the following symptoms:

• Shock (anaphylaxis): Itchy skin, hives, a hoarse voice, sneezing, an itchy throat, difficulty breathing, palpitations, or clouded consciousness soon after using the medicine.
• Pseudoaldosteronism (偽アルドステロン症) and myopathy (ミオパチー): Tiredness in the arms and legs, numbness, a tight or stiff feeling, then weakness and muscle pain that slowly get stronger.

If symptoms have not improved after using it for about 10 days, stop using it and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Storage:

Store at 1 to 30°C. It is designed to melt at body temperature, so keep it in a cool place away from direct sunlight. Even after opening, put the suppositories back in the outer box with the tips pointing down, and store the box standing upright as the mark on it shows. Avoid storing it at 0°C or below, which can cause cracks. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not use it after the expiry date. A melted suppository can leak out after insertion and be hard to remove from clothes.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert (revised April 2017) and the product page. Borraginol M Suppositories information checked October 1, 2026.

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Classification:

Class 2 medicine (第2類医薬品). It is not the designated Class 2 (指定第2類) that the Borraginol A products carry.

Do not use:

• If you have had an allergic reaction to this medicine or any of its ingredients.

Instructions for use:

• Ages 15 and over: Apply a suitable amount, 1 to 3 times a day. Apply it directly to the affected area, or spread it on gauze and stick that on the area.
• Under 15: Do not use this medicine.
• Use only on the anus.
• Follow the dosage directions strictly.
• Take an amount that covers the affected area onto a clean finger and apply it as it is, or spread it on gauze.
• To open the tube, turn the cap around and press the raised part of the cap firmly onto the tip of the tube.
• If the ointment has become hard to squeeze because of cold weather or cold storage, hold the tube in your hand to warm it. It will soften.

Inactive ingredients:

White petrolatum, medium-chain fatty acid triglyceride, glyceryl monostearate. The ointment is white to slightly yellowish white.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Have had an allergic reaction to a medicine or other substance.

When to stop and seek advice:

If any of the following appear after using this medicine, they may be side effects. Stop using it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, itching, or swelling.
• Other: A stinging or irritated feeling.

If symptoms have not improved after using it for about 10 days, stop using it and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Pregnancy:

The package insert does not list pregnancy among the reasons to consult first. The manufacturer's product page says Borraginol M Ointment can be used during pregnancy, and asks you to consult a doctor, pharmacist, or registered salesperson before using its other Borraginol products.

Storage:

Store in a cool place away from direct sunlight, with the cap shut tight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not use it after the expiry date. The ointment is oil-based, so it can be hard to remove if it gets on clothes. Do not bend the tube back and forth repeatedly, as it can tear.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert (revised April 2017) and the product page. Borraginol M Ointment information checked October 1, 2026.

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Classification:

Designated Class 2 medicine (指定第2類医薬品). On the box and the package insert it is printed as 第2類医薬品 with the 2 inside a square. The manufacturer's information sheet for stores marks it 指定第二類医薬品.

Do not use:

• If the affected area is festering with pus.

Do not:

• Use it for a long time.

Instructions for use:

• Apply a suitable amount to the affected area, 3 times a day.
• Follow the dosage directions strictly.
• If a child uses it, an adult must supervise and guide.
• Use only on the anus.
• If the ointment has become hard to squeeze because of cold, hold the tube in your hand for a while to warm it before use.

Inactive ingredients:

Squalane, cetanol, petrolatum (ワセリン).

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Are pregnant or may be pregnant.
• Have had an allergic reaction to a medicine or other substance.

When to stop and seek advice:

If any of the following appear after using this medicine, they may be side effects. Stop using it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, itching, or swelling.
• Other: A stinging or irritated feeling, or festering with pus.

If symptoms have not improved after using it for about 10 days, stop using it and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Storage:

Store in a cool place with low humidity, away from direct sunlight, with the cap shut tight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not use it after the expiry date.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert (revised February 2013) and the product page. G4 L Ointment information checked October 1, 2026.

Close details

Classification:

Designated Class 2 medicine (指定第2類医薬品). On the box and the package insert it is printed as 第2類医薬品 with the 2 inside a square. The manufacturer's information sheet for stores marks it 指定第二類医薬品.

Do not use:

• If you have had an allergic reaction to this medicine or any of its ingredients.
• If the affected area is festering with pus.

Do not use with:

• Oral medicines that contain an antihistamine (抗ヒスタミン剤): cold medicines, cough and phlegm medicines, nasal allergy medicines, motion sickness medicines, and allergy medicines.

Do not:

• Drive or operate machinery after using it. Drowsiness may occur.
• Use it while breastfeeding, or avoid breastfeeding if you do use it.
• Use it for a long time.

Instructions for use:

• Ages 15 and over: Insert 1 suppository into the anus per dose, 1 to 2 times a day.
• Under 15: Do not use this medicine. The insert also says not to let a child use it.
• Follow the dosage directions strictly.
• If the suppository is soft, cool it for a while before use. If it is too hard, wait until it has softened.
• Use only in the anus.

How to take it out and insert it:

• Cut one suppository off the plastic pack at the notch.
• Peel the seam of the plastic pack apart, slowly, to the left and right, and take the suppository out.
• Melt the surface a little with the warmth of your hand, then insert the thicker end first.
• Hold the base of the suppository and push it in with your finger until it is fully inside the anus.

Inactive ingredients:

Silicic anhydride, magnesium aluminometasilicate (メタケイ酸アルミン酸Mg), hydroxypropyl cellulose, squalane, starch acrylate (アクリル酸デンプン), hard fat. The manufacturer's product page says the starch acrylate swells with moisture so the suppository stays near the affected area, and that the lidocaine is released slowly from special granules.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Are pregnant or may be pregnant.
• Have had an allergic reaction to a medicine or other substance.
• Have difficulty urinating.
• Have been diagnosed with glaucoma.

When to stop and seek advice:

If any of the following appear after using this medicine, they may be side effects. Stop using it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, itching, or swelling.
• Urinary: Difficulty urinating.
• Other: A stinging or irritated feeling, festering with pus, or unusual glare.

Rare but serious reactions may occur. Seek medical attention immediately if you develop the following symptoms:

• Shock (anaphylaxis): Itchy skin, hives, a hoarse voice, sneezing, an itchy throat, difficulty breathing, palpitations, or clouded consciousness soon after using the medicine.

If dry mouth or drowsiness appears and keeps up or gets worse, stop using this medicine and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

If symptoms have not improved after using it for about 10 days, stop using it and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Storage:

Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. The suppository is made to melt easily at body temperature, so avoid direct sunlight and high temperatures. Store it at 30°C or below, in a place with low humidity. Stand the outer box upright, following the mark on it, so that the tip of the suppository (the thicker end) points down. Even if the suppository melts or softens in the heat, this keeps its shape. Do not use it after the expiry date.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert (revised May 2013) and the product page. G4 L Suppositories information checked October 1, 2026.

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Classification:

Designated Class 2 medicine (指定第2類医薬品). On the box and the package insert it is printed as 第2類医薬品 with the 2 inside a square. The manufacturer's information sheet for stores marks it 指定第二類医薬品.

Do not use:

• If you have had an allergic reaction to this medicine or any of its ingredients.
• If the affected area is festering with pus.

Do not:

• Use it for a long time.

Instructions for use:

To inject it into the anus: Put the nozzle into the anus and inject the whole amount slowly.

• Ages 15 and over: 1 applicator per dose, 1 to 2 times a day.
• Under 15: Do not use this medicine.
• Take off the cap, squeeze the body of the applicator, and push a little ointment out of the tip.
• Put the nozzle into the anus, press the body, and inject slowly. Pull it out while still pressing.
• Inject the whole amount in one go.

To apply it to the skin around the anus: Apply the following amount to the area. Once you have used an applicator to apply the ointment, do not use it to inject.

• Ages 15 and over: A suitable amount, 1 to 3 times a day.
• Under 15: Do not use this medicine.
• Take off the cap and apply the ointment straight onto the area.

Follow the dosage directions strictly. Do not let a child use it. Use only on the anus.

Inactive ingredients:

Liquid paraffin, glyceryl monostearate, polyglyceryl polyricinoleate (縮合リシノレイン酸ポリグリセリル), white petrolatum.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Are pregnant or may be pregnant.
• Have had an allergic reaction to a medicine or other substance.

When to stop and seek advice:

If any of the following appear after using this medicine, they may be side effects. Stop using it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, itching, or swelling.
• Other: A stinging or irritated feeling, or festering with pus.

Rare but serious reactions may occur. Seek medical attention immediately if you develop the following symptoms:

• Shock (anaphylaxis): Itchy skin, hives, a hoarse voice, sneezing, an itchy throat, difficulty breathing, palpitations, or clouded consciousness soon after using the medicine.

If symptoms have not improved after using it for about 10 days, stop using it and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Storage:

Store in a cool place with low humidity, away from direct sunlight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not use it after the expiry date. Do not flush used applicators down the toilet.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert (revised February 2013) and the product page. G4 L Injection Ointment information checked October 1, 2026.

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Classification:

Designated Class 2 medicine (指定第2類医薬品), as marked on the Amazon listing. The manufacturer's product page prints 第2類医薬品 with the 2 inside a square.

Do not use:

• If you have had an allergic reaction to this medicine, any of its ingredients, or chlorhexidine (クロルヘキシジン).
• If the affected area is festering with pus.

Do not:

• Use it for a long time.

Instructions for use:

• Ages 15 and over: Insert 1 suppository into the anus per dose, 1 to 3 times a day.
• Under 15: Do not use this medicine.
• Follow the dosage directions strictly.
• It works best if you take a bath first, or clean the area with lukewarm water. In the morning, use it after a bowel movement. At night, use it before going to sleep.
• If the suppository is soft, cool it for a while before use. If it is too hard, wait until it has softened.
• Use only in the anus.

How to take it out and insert it:

• Separate one suppository from the strip at the perforation.
• Pull the seam of the pack apart to the left and right and take the suppository out.
• Insert it into the anus. Sitting down, put the suppository in, press on it with your hand, tighten the anus, and stand up slowly. This makes it easy to insert.

Inactive ingredients:

Carboxyvinyl polymer, silicic anhydride, glyceryl stearate, hard fat.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Are pregnant or may be pregnant.
• Have had an allergic reaction to a medicine or other substance.

When to stop and seek advice:

If any of the following appear after using this medicine, they may be side effects. Stop using it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, itching, or swelling.
• Other: A stinging or irritated feeling, or festering with pus.

Rare but serious reactions may occur. Seek medical attention immediately if you develop the following symptoms:

• Shock (anaphylaxis): Itchy skin, hives, a hoarse voice, sneezing, an itchy throat, difficulty breathing, palpitations, or clouded consciousness soon after using the medicine.

If symptoms have not improved after using it for about 10 days, stop using it and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Storage:

Store at 30°C or below, in a cool place with low humidity, away from direct sunlight. Keep out of reach of children. Put the suppositories back in the outer box with the tips pointing down, and stand the box upright as the mark on it shows. Do not transfer to another container, as this may cause misuse or affect the quality. Do not use it after the expiry date. Even within the expiry date, use it as soon as you can after opening, to keep the quality.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert and the product page. Preser Ace Suppositories information checked October 1, 2026.

Close details

Classification:

Designated Class 2 medicine (指定第2類医薬品), as marked on the Amazon listing. The manufacturer's product page and the box print 第2類医薬品 with the 2 inside a square.

Do not use:

• If you have had an allergic reaction to this medicine, any of its ingredients, or chlorhexidine (クロルヘキシジン).
• If the affected area is festering with pus.

Do not:

• Use it for a long time.

Instructions for use:

To inject it into the anus: Put the tip of the applicator into the anus and inject the whole amount.

• Ages 15 and over: 1 applicator per dose, 1 to 3 times a day.
• Under 15: Do not use this medicine.
• Take off the cap and push out a little ointment to make insertion smooth.
• Put the tip of the applicator into the anus and press the applicator to inject the ointment. Pull it out while still pressing.
• Inject the whole amount in one go.
• Put in only the tip of the applicator.

To apply it to the skin around the anus: Apply the following amount to the area. Once you have used an applicator to apply the ointment, do not use it to inject.

• Ages 15 and over: A suitable amount, 1 to 3 times a day.
• Under 15: Do not use this medicine.
• Take off the cap and apply the ointment straight onto the area, or spread it on gauze and put that on the area.
• If the ointment is too hard to squeeze, hold the applicator in your hand to warm it. It will soften.

Follow the dosage directions strictly. Do not let a child use it. Use only on the anus. A small amount of ointment stays in the applicator because it is an injection type. The manufacturer fills each applicator with that in mind.

Inactive ingredients:

Liquid paraffin, isopropyl myristate, bleached beeswax (サラシミツロウ), carboxyvinyl polymer, olive oil, petrolatum.

Consult a doctor, pharmacist, or registered salesperson before use if you:

• Are receiving treatment from a doctor.
• Are pregnant or may be pregnant.
• Have had an allergic reaction to a medicine or other substance.

When to stop and seek advice:

If any of the following appear after using this medicine, they may be side effects. Stop using it at once and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you:

• Skin: Rash, redness, itching, or swelling.
• Other: A stinging or irritated feeling, or festering with pus.

Rare but serious reactions may occur. Seek medical attention immediately if you develop the following symptoms:

• Shock (anaphylaxis): Itchy skin, hives, a hoarse voice, sneezing, an itchy throat, difficulty breathing, palpitations, or clouded consciousness soon after using the medicine.

If symptoms have not improved after using it for about 10 days, stop using it and consult a doctor, pharmacist, or registered salesperson, taking the package insert with you.

Storage:

Store in a cool place with low humidity, away from direct sunlight. Keep out of reach of children. Do not transfer to another container, as this may cause misuse or affect the quality. Do not use it after the expiry date. Even within the expiry date, use it as soon as you can after opening, to keep the quality. Do not flush used applicators down the toilet.

Source: Japanese package insert (PDF) · Manufacturer product page
Translated from the Japanese insert and the product page. Preser Ace Injection Ointment information checked October 1, 2026.

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